Description

n-(2-Chloro-4-Methyl-3-Pyridinyl)-2-(Cyclopropyl-D5-Amino)-3-Pyridine-Carboxamide is a high-purity, deuterated chemical intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a stable isotope-labeled compound, which is essential for conducting precise metabolism, pharmacokinetic (PK), and bioanalytical studies. This compound is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development of novel therapeutic agents, where deuterium labeling is used to trace molecular pathways and improve drug properties.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of deuterated active pharmaceutical ingredients (APIs) for clinical research.
• Metabolic Tracer: Used in drug metabolism and pharmacokinetics (DMPK) studies to track and quantify the fate of drug molecules in biological systems via mass spectrometry.
• Internal Standard for Bioanalysis: Essential for the accurate quantification of target analytes in complex biological matrices using LC-MS/MS methods, ensuring reliable data.
• Mechanism of Action (MoA) Studies: Facilitates research into the biochemical pathways and mechanisms of drug candidates.
• Isotope Dilution Mass Spectrometry (IDMS): Employed as a high-purity standard for precise quantitative analysis in advanced analytical chemistry.
• Development of Deuterated Drugs: A key precursor in creating drugs with deuterium substitution, a strategy used to potentially enhance metabolic stability and efficacy.

Basic Information

Product Name	n-(2-Chloro-4-Methyl-3-Pyridinyl)-2-(Cyclopropyl-D5-Amino)-3-Pyridine-Carboxamide
CAS No.	1184978-88-8
Molecular Formula	C15H10D5ClN4O
Molecular Weight	307.80 g/mol
Synonyms	2-(Cyclopropyl-d5-amino)-N-(2-chloro-4-methylpyridin-3-yl)nicotinamide; Deuterated Cyclopropyl Nicotinamide Derivative; (Cyclopropyl-d5)amino Pyridinecarboxamide; 1184978-88-8; 2-[(Cyclopentyl-d5)amino]-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide; Deuterium Labeled Kinase Inhibitor Intermediate; Perdeuterated Cyclopropylamine Analog
EINECS	Contact for details

Quality Control

Our n-(2-Chloro-4-Methyl-3-Pyridinyl)-2-(Cyclopropyl-D5-Amino)-3-Pyridine-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and isotopic enrichment, NMR for structural confirmation, and mass spectrometry to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and data integrity for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.