Description

4-Hydroxy Triamterene-D4 is a deuterium-labeled internal standard of the active metabolite of the potassium-sparing diuretic triamterene. This high-purity reference material is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolism studies. It is a critical component for pharmaceutical research and development laboratories, clinical testing facilities, and contract research organizations (CROs) requiring precise analytical measurements.

Application

• Internal Standard for LC-MS/MS: Primary use as a stable isotope-labeled internal standard for the precise quantification of 4-hydroxy triamterene and related compounds in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug metabolite formation, distribution, and elimination in preclinical and clinical studies.
• Bioanalytical Method Development & Validation: Serves as a critical reference compound for developing, optimizing, and validating robust HPLC and mass spectrometry-based assays.
• Clinical Research & Therapeutic Drug Monitoring (TDM): Supports studies investigating patient adherence, drug-drug interactions, and individualized dosing regimens for diuretic therapies.
• Pharmaceutical Impurity Profiling: Used as a reference standard to identify and quantify related substances and degradation products in active pharmaceutical ingredient (API) and finished drug product analysis.
• Forensic and Anti-Doping Analysis: Provides a definitive reference for the confirmation of triamterene and its metabolites in forensic toxicology and sports drug testing.

Basic Information

Product Name	4-Hydroxy Triamterene-D4
CAS No.	1184977-36-3
Molecular Formula	C12H7D4N5O
Molecular Weight	217.25 g/mol
Synonyms	2,4,7-Triamino-6-(4-hydroxyphenyl)pteridine-D4; 4-Hydroxytriamterene-D4; 6-(4-Hydroxyphenyl)-2,4,7-pteridinetriamine-D4; Triamterene metabolite D4; 4-OH-Triamterene-D4; [2H4]-4-Hydroxytriamterene; Deuterated 4-Hydroxy Triamterene
EINECS	Contact for details

Quality Control

Every batch of 4-Hydroxy Triamterene-D4 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and include detailed results for identity, purity (HPLC), isotopic enrichment, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D4)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.