Description

4-Carboxytolbutamide-D9 is a stable isotope-labeled analog of the tolbutamide metabolite, 4-Carboxytolbutamide, where nine hydrogen atoms are replaced by deuterium. This compound is essential as a high-purity internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in mass spectrometry-based analyses. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers for pharmacokinetic studies, drug metabolism research, and clinical diagnostics.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of 4-Carboxytolbutamide in biological matrices (plasma, serum, urine) during bioanalytical method development and validation.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to understand the metabolic profile and clearance pathways of Tolbutamide and related sulfonylurea drugs.
• Clinical Research: Supports therapeutic drug monitoring and pharmacokinetic studies in clinical trials for diabetes medications.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of metabolite-related impurities in drug substances and products.
• Forensic and Toxicology Analysis: Employed in confirmatory testing for the presence of sulfonylurea drugs in forensic investigations.
• Stable Isotope Labeled Reference Material: Serves as a certified reference material (CRM) for calibrating analytical instruments and ensuring data integrity in regulated laboratories.

Basic Information

Product Name	4-Carboxytolbutamide-D9
CAS No.	1184973-50-9
Molecular Formula	C12H9D9N2O4S
Molecular Weight	295.38 g/mol
Synonyms	1-Butyl-3-[(4-carboxyphenyl)sulfonyl]-1-(trideuteriomethyl)(2H3)urea; 4-Carboxy Tolbutamide D9; 4-Carboxytolbutamide-d9; 1-Butyl-3-(p-carboxyphenylsulfonyl)-1-(methyl-d3)urea-2,3,4,5,6-d5; Deuterated 4-Carboxytolbutamide; 4-Carboxy Tolbutamide Deuterated; 4-CTB-D9; Stable Isotope Labeled 4-Carboxytolbutamide
EINECS	Contact for details

Quality Control

Our 4-Carboxytolbutamide-D9 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and purity by HPLC. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable performance as an internal standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98 atom % D
Chemical Purity (by HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.