Description

Carazolol-D6, Hydrochloride Salt is a high-purity, deuterium-labeled internal standard essential for precise quantitative analysis in bioanalytical research. This stable isotope-labeled compound is critical for ensuring accuracy and reliability in mass spectrometry-based assays by correcting for variations in sample preparation and instrument response. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical chemists working on pharmacokinetic studies, drug metabolism research, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in the analysis of Carazolol and its metabolites in biological matrices like plasma, serum, and urine.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate measurement of drug concentration over time to determine absorption, distribution, metabolism, and excretion (ADME) profiles.
• Doping Control & Forensic Analysis: Supports the detection and confirmation of the β-blocker Carazolol in sports anti-doping programs and forensic investigations.
• Method Development & Validation: Serves as a key component in developing and validating robust, regulatory-compliant bioanalytical methods (e.g., following FDA/EMA guidelines).
• Metabolite Identification & Profiling: Aids in the identification and quantification of drug metabolites using high-resolution mass spectrometry.
• Quality Control in Reference Material Production: Used in the preparation and certification of certified reference materials (CRMs) for Carazolol.

Basic Information

Product Name	Carazolol-D6, Hydrochloride Salt
CAS No.	1184973-07-6
Molecular Formula	C18H17D6ClN2O2 • HCl
Molecular Weight	381.33 g/mol (approx.)
Synonyms	1-(4-Carbazolyloxy)-3-[(1-methylethyl)amino]-2-propanol-D6 Hydrochloride; 1-(Carbazol-4-yloxy)-3-(isopropylamino)-2-propanol-D6 Hydrochloride; Carazolol-d6 HCl; [2H6]-Carazolol Hydrochloride; 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-9H-carbazole-D6 Hydrochloride; BM 51052-d6; Suacron-d6 (deuterated variant)
EINECS	Contact for details

Quality Control

Every batch of Carazolol-D6, Hydrochloride Salt is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data from techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), isotopic enrichment (≥98 atom % D), and other critical specifications to meet the stringent requirements of analytical and regulatory laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.