Description

Methaqualone-D5 CAS NO 1184966-71-9 is a deuterated internal standard of the sedative-hypnotic compound methaqualone, where five hydrogen atoms are replaced with deuterium. This isotopic labeling is critical for ensuring accuracy and reliability in quantitative analytical techniques. It is an essential reference material for forensic laboratories, pharmaceutical research, and clinical toxicology programs requiring precise measurement and confirmation of methaqualone levels.

Application

• Quantitative Analytical Internal Standard: Used as a critical reference in LC-MS/MS and GC-MS methods for the accurate quantification of methaqualone in complex biological matrices.
• Forensic Science and Drug Testing: Essential for confirmatory testing in workplace drug screening, post-mortem toxicology, and law enforcement investigations to ensure legally defensible results.
• Pharmaceutical Metabolism and Pharmacokinetic (PK) Studies: Employed in research to track drug absorption, distribution, metabolism, and excretion (ADME) with high precision.
• Clinical Toxicology and Therapeutic Drug Monitoring (TDM): Supports laboratories in monitoring patient compliance or investigating potential overdoses.
• Method Development and Validation: Serves as a key component in developing, optimizing, and validating new analytical protocols to meet regulatory standards (e.g., CLIA, ISO/IEC 17025).
• Quality Control for Reference Material Producers: Used by manufacturers to certify the purity and concentration of their own methaqualone calibrators and controls.

Basic Information

Product Name	Methaqualone-D5
CAS No.	1184966-71-9
Molecular Formula	C16H9D5N2O
Molecular Weight	257.33 g/mol
Synonyms	2-Methyl-3-(2-methylphenyl)-4(3H)-quinazolinone-D5; 2-Methyl-3-o-tolyl-4(3H)-quinazolinone-D5; Deuterated Methaqualone (D5); Methaqualone-d5; [2H5]-Methaqualone; Quaalude-D5; Internal Standard Methaqualone-D5
EINECS	Contact for details

Quality Control

Every batch of Methaqualone-D5 is produced and analyzed under strict quality management protocols to ensure the high isotopic purity and chemical integrity required for sensitive analytical applications. Comprehensive testing includes NMR and mass spectrometry for isotopic enrichment confirmation, alongside HPLC for chemical purity assessment. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to reference mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.