Description

4-(2,2-Dimethylpropanamido)Cyclohexane-1-Carboxylic Acid is a high-purity, specialized organic building block featuring a cyclohexane carboxylic acid core modified with a pivalamido substituent. This compound matters as a critical chiral intermediate for the synthesis of advanced pharmaceutical compounds and fine chemicals, offering a unique sterically hindered amide linkage. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and advanced material sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides where its structural motif contributes to biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics Research: The pivalamido-protected cyclohexane carboxylic acid structure is valuable for designing peptide analogs and conformationally restricted biomolecules.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for high-value, low-volume specialty chemicals.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic synthesis, including amide coupling and stereoselective transformations.

Basic Information

Product Name	4-(2,2-Dimethylpropanamido)Cyclohexane-1-Carboxylic Acid
CAS No.	1184664-82-1
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	4-Pivalamidocyclohexanecarboxylic Acid; 4-(Pivalamido)cyclohexanecarboxylic Acid; 4-[(2,2-Dimethylpropanoyl)amino]cyclohexane-1-carboxylic Acid; 4-(2,2-Dimethylpropanoylamino)cyclohexanecarboxylic Acid; Cyclohexanecarboxylic acid, 4-[(2,2-dimethyl-1-oxopropyl)amino]-; 4-(Tert-butylcarbonylamino)cyclohexanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 4-(2,2-Dimethylpropanamido)Cyclohexane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure compliance with exacting customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.