Description

2-(Chloromethyl)-1,3-Difluoro-5-Methoxybenzene is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique reactivity, where the chloromethyl group and fluorine atoms serve as versatile handles for constructing complex molecular architectures. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in fluorinated small molecule libraries.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where fluorination enhances bioactivity and stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various palladium-catalyzed and other metal-mediated coupling reactions.
• Fluorine Chemistry Research: A valuable substrate for studying nucleophilic aromatic substitution and other reactions involving activated fluorine atoms.
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value fluorinated compounds for various industrial applications.

Basic Information

Product Name	2-(Chloromethyl)-1,3-Difluoro-5-Methoxybenzene
CAS No.	1183153-32-3
Molecular Formula	C8H7ClF2O
Molecular Weight	192.59 g/mol
Synonyms	1-(Chloromethyl)-3,5-Difluoro-4-Methoxybenzene; 3,5-Difluoro-4-Methoxybenzyl Chloride; 4-Methoxy-3,5-difluorobenzyl Chloride; 2-Chloromethyl-1,3-difluoro-5-methoxybenzene; 3,5-Difluoro-4-methoxybenzylchloride; 5-Methoxy-2-(chloromethyl)-1,3-difluorobenzene; 1,3-Difluoro-5-methoxy-2-(chloromethyl)benzene
EINECS	Contact for details

Quality Control

Our 2-(Chloromethyl)-1,3-Difluoro-5-Methoxybenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.