Description

1-Bromo-2-(Chloromethyl)-3-Fluorobenzene is a versatile halogenated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of three distinct halogen substituents, which serve as reactive handles for sequential functionalization and the construction of complex molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing complex fluorinated and halogenated aromatic cores.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom can enhance biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic materials with tailored electronic or physical properties.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated ligands for transition metal catalysis and organocatalysts.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological systems, leveraging its reactive halomethyl and halogen sites.
• Cross-Coupling Reactions: Acts as a substrate in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the bromine substituent.

Basic Information

Product Name	1-Bromo-2-(Chloromethyl)-3-Fluorobenzene
CAS No.	1182357-16-9
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	2-Bromo-1-(chloromethyl)-3-fluorobenzene; 3-Fluoro-2-bromobenzyl chloride; 1-Bromo-2-(chloromethyl)-3-fluorobenzene; 2-Bromobenzyl chloride, 3-fluoro-; 3-Fluoro-2-bromobenzyl chloride; Benzene, 1-bromo-2-(chloromethyl)-3-fluoro-; (3-Fluoro-2-bromophenyl)methyl chloride
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(Chloromethyl)-3-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to the light-sensitive and reactive nature of the halomethyl group, prolonged exposure to light or moisture should be avoided.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.