Description

Trazodone-D6 Hydrochloride CAS NO 1181578-71-1 is a deuterated internal standard of the antidepressant trazodone, where six hydrogen atoms are replaced with stable deuterium isotopes. This high-purity compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry-based analyses. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities for pharmacokinetic studies, drug metabolism research, and bioanalytical method development and validation.

Application

• Internal Standard for LC-MS/MS quantification of trazodone and its metabolites in biological matrices (plasma, serum, urine).
• Bioanalytical method development and validation in accordance with FDA and ICH guidelines.
• Pharmacokinetic (PK) and pharmacodynamic (PD) studies in clinical and preclinical research.
• Drug metabolism and disposition (DMPK) studies to track the parent drug.
• Forensic toxicology analysis for the accurate measurement of trazodone levels.
• Quality control in pharmaceutical manufacturing for impurity profiling and assay verification.

Basic Information

Product Name	Trazodone-D6 Hydrochloride
CAS No.	1181578-71-1
Molecular Formula	C19H16D6ClN5O•HCl
Molecular Weight	408.35 g/mol
Synonyms	2-[3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one-D6 Hydrochloride; Desyrel-D6 HCl; Molipaxin-D6 HCl; Trazodone-d6 HCl; 1-{3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl}-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one-d6 hydrochloride; Deuterated Trazodone Hydrochloride
EINECS	Contact for details

Quality Control

Our Trazodone-D6 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment, and impurity profiles. We adhere to relevant industry standards for reference materials to ensure reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Enrichment	≥99.0 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.