Description

1-(4-(Difluoromethoxy)-3-Fluorophenyl)Ethan-1-One is a high-purity fluorinated aromatic ketone building block, serving as a critical intermediate in advanced organic synthesis. Its value lies in its unique difluoromethoxy and fluoro substituents, which are strategically important for modulating the physicochemical and metabolic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved biological activity and environmental profile.
• Material Science Research: Serves as a precursor for synthesizing specialty polymers and liquid crystals that require fluorinated aromatic units for specific thermal, optical, or chemical resistance properties.
• Organic Electronics: Employed in the development of novel organic semiconductors and electroactive materials due to the electron-withdrawing nature of the fluorinated groups.
• Chemical Biology & Proteomics: Utilized as a building block for creating chemical probes and affinity tags to study biological systems and protein functions.

Basic Information

Item	Details
Product Name	1-(4-(Difluoromethoxy)-3-Fluorophenyl)Ethan-1-One
CAS No.	1180015-83-1
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	1-[4-(Difluoromethoxy)-3-fluorophenyl]ethanone; 4'-Difluoromethoxy-3'-fluoroacetophenone; 3-Fluoro-4-(difluoromethoxy)acetophenone; 1-Acetyl-4-(difluoromethoxy)-3-fluorobenzene; DFMOF-Acetophenone; (4-(Difluoromethoxy)-3-fluorophenyl)methyl ketone; Ethanone, 1-[4-(difluoromethoxy)-3-fluorophenyl]-
EINECS	Contact for details

Quality Control

Our 1-(4-(Difluoromethoxy)-3-Fluorophenyl)Ethan-1-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and relevant industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.