Description

2-(4-(2,2-Difluoroethoxy)Phenyl)Acetonitrile is a high-value, fluorinated organic building block of significant interest in advanced chemical synthesis. Its core value lies in its unique molecular structure, which incorporates both a phenylacetonitrile moiety and a difluoroethoxy group, making it a versatile intermediate for constructing complex molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, where the introduction of fluorine atoms is a key strategy to modulate biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for incorporating fluorinated aromatic ether motifs into active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the difluoroethoxy group can enhance bioavailability and environmental stability.
• Liquid Crystal & OLED Material Synthesis: Serves as a building block for advanced electronic and display materials requiring specific fluorinated aromatic components.
• Organic Synthesis & Chemical Research: A versatile reagent for constructing complex organic frameworks in academic and industrial R&D settings, enabling novel carbon-carbon and carbon-heteroatom bond formations.
• Fluorine Chemistry Studies: Employed as a model compound or intermediate in research focused on the properties and reactions of organofluorine compounds.

Basic Information

Product Name	2-(4-(2,2-Difluoroethoxy)Phenyl)Acetonitrile
CAS No.	1179604-29-5
Molecular Formula	C10H9F2NO
Molecular Weight	197.18 g/mol
Synonyms	4-(2,2-Difluoroethoxy)benzyl cyanide; [4-(2,2-Difluoroethoxy)phenyl]acetonitrile; 2-[4-(2,2-Difluoroethoxy)phenyl]acetonitrile; 2-(4-(2,2-Difluoroethoxy)phenyl)ethanenitrile; α-(4-(2,2-Difluoroethoxy)phenyl)acetonitrile; (4-(2,2-Difluoroethoxyphenyl))acetonitrile; DFEPA; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2-(4-(2,2-Difluoroethoxy)Phenyl)Acetonitrile is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive R&D and scale-up processes. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry for identity confirmation and purity assessment. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.