Description

2-n-Cbz-Propane-1,2-Diamine-Hcl is a protected diamine derivative, specifically the hydrochloride salt of a Cbz (carboxybenzyl)-protected 1,2-diaminopropane analog. This compound serves as a critical chiral building block in the synthesis of complex molecules, offering precise control over stereochemistry and functional group manipulation. It is primarily utilized by pharmaceutical research and development teams for constructing active pharmaceutical ingredients (APIs), peptide mimetics, and specialized ligands.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetic Chemistry: Used to introduce constrained diamine backbones into peptide analogs to enhance metabolic stability and bioavailability.
• Ligand Synthesis: Serves as a precursor for creating chiral ligands used in asymmetric catalysis for enantioselective transformations.
• Chemical Biology Probes: Employed in the development of molecular probes and tools for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects under GMP guidelines.

Basic Information

Item	Details
Product Name	2-n-Cbz-Propane-1,2-Diamine-Hcl
CAS No.	1179361-49-9
Molecular Formula	C11H17ClN2O2
Molecular Weight	244.72 g/mol
Synonyms	1,2-Diaminopropane, N2-[(benzyloxy)carbonyl]-, hydrochloride (1:1); (1R)-2-[[(Benzyloxy)carbonyl]amino]-1-methyl-ethylamine hydrochloride; N-Cbz-1,2-diaminopropane hydrochloride; Cbz-DAP.HCl; N2-Cbz-1,2-diaminopropane hydrochloride; (R)-2-((((Benzyloxy)carbonyl)amino)propylamine hydrochloride; 2-[(Benzyloxycarbonyl)amino]propylamine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-n-Cbz-Propane-1,2-Diamine-Hcl is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are available for every batch. For advanced applications, we can supply material produced under GMP-like conditions with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.