Description

4-Aminobenzoyl-n-Hydroxysuccinimidyl Carbamate is a high-purity, bifunctional chemical linker designed for the covalent conjugation of biomolecules. This compound matters because it provides a reliable and efficient method for introducing stable amide bonds, crucial for creating targeted probes, diagnostics, and drug conjugates. It is essential for researchers and manufacturers in the pharmaceutical, biotech, and diagnostic industries who require precise and reproducible cross-linking in antibody-drug conjugates (ADCs), peptide synthesis, and protein labeling applications.

Application

• Antibody-Drug Conjugate (ADC) Synthesis: A key reagent for linking cytotoxic payloads to monoclonal antibodies via lysine residues.
• Peptide & Protein Labeling: Used to attach fluorophores, biotin, or other reporter molecules to peptides and proteins for detection and analysis.
• Diagnostic Assay Development: Facilitates the immobilization of antigens or antibodies onto solid supports for ELISA and other immunoassays.
• Bioconjugation & Cross-linking: Enables the creation of stable conjugates between various biomolecules for research and therapeutic purposes.
• Surface Functionalization: Employed to modify nanoparticles, microspheres, or biosensor surfaces with amine-reactive groups.
• Small Molecule Prodrug Development: Serves as a cleavable linker in the design of targeted prodrugs and controlled-release systems.

Basic Information

Product Name	4-Aminobenzoyl-n-Hydroxysuccinimidyl Carbamate
CAS No.	1178554-79-4
Molecular Formula	C12H11N3O5
Molecular Weight	277.23 g/mol
Synonyms	4-((((2,5-Dioxopyrrolidin-1-yl)oxy)carbonyl)amino)benzamide; 4-Aminobenzoyl NHS Carbamate; AB-NHS Carbamate; 4-Abz-OSu; N-Hydroxysuccinimide 4-Aminobenzoyl Carbamate; 4-Carbamoylphenyl N-succinimidyl carbonate; p-Aminobenzoyl-NHS carbamate; NHS-4-Aminobenzoyl Carbamate
EINECS	Contact for details

Quality Control

Our 4-Aminobenzoyl-n-Hydroxysuccinimidyl Carbamate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive bioconjugation applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers in pharmaceutical development and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under desiccant and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO; slightly soluble in acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.