Description

3,5-Difluoro-4-Methoxybenzenesulfonyl Chloride is a high-purity, multi-functional sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which enables the precise introduction of a sulfonamide or sulfonate group into complex molecular architectures under controlled conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients, intermediates, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used to construct active ingredients for herbicides, fungicides, and pesticides, leveraging the fluorine atoms for enhanced bioactivity and environmental stability.
• Material Science: Employed in the production of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and the development of activity-based probes and affinity labels.
• Custom Synthesis & Contract Manufacturing: Serves as a versatile starting material for bespoke chemical synthesis and scale-up projects under GMP or non-GMP conditions.
• Dye & Pigment Industry: Utilized in the synthesis of specialized dyes and pigments where sulfonyl groups impart specific solubility and color-fastness properties.

Basic Information

Product Name	3,5-Difluoro-4-Methoxybenzenesulfonyl Chloride
CAS No.	1178236-98-0
Molecular Formula	C7H5ClF2O3S
Molecular Weight	242.63 g/mol
Synonyms	4-Methoxy-3,5-difluorobenzenesulfonyl chloride; 3,5-Difluoro-4-methoxybenzene-1-sulfonyl chloride; 1-(Chlorosulfonyl)-3,5-difluoro-4-methoxybenzene; 3,5-Difluoro-4-methoxyphenylsulfonyl chloride; 4-Methoxy-3,5-difluorophenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-Methoxybenzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.