Description

2-((4-Bromophenyl)Sulfonyl)-2-Methylpropanenitrile is a specialized organic sulfone derivative featuring a bromophenyl group and a nitrile functionality. This compound serves as a valuable high-purity chemical intermediate for advanced synthesis in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the fine chemical industry for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging the sulfone moiety for biological activity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers with unique thermal or chemical resistance properties.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) due to the presence of the bromine atom, enabling complex bond formation.
• Ligand and Catalyst Development: Utilized as a precursor for creating novel ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	2-((4-Bromophenyl)Sulfonyl)-2-Methylpropanenitrile
CAS No.	1178187-96-6
Molecular Formula	C10H10BrNO2S
Molecular Weight	288.16 g/mol
Synonyms	2-((4-Bromophenyl)sulfonyl)-2-methylpropanenitrile; 2-Methyl-2-[(4-bromophenyl)sulfonyl]propanenitrile; Propanenitrile, 2-((4-bromophenyl)sulfonyl)-2-methyl-; α-((4-Bromophenyl)sulfonyl)isobutyronitrile; 4-Bromo-α-(methylsulfonyl)benzenepropanenitrile; (4-Bromophenyl)(cyano-dimethyl-methyl)sulfone; 2-(4-Bromobenzenesulfonyl)-2-methylpropionitrile
EINECS	Contact for details

Quality Control

Our production of 2-((4-Bromophenyl)Sulfonyl)-2-Methylpropanenitrile adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical intermediate applications, with documentation available for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.