Description

5-Bromo-3-Fluoro-n-Boc-Benzylamine is a high-purity, protected amine building block of significant importance in modern synthetic chemistry. Its value lies in its dual functionality, offering a reactive benzylamine group protected by a Boc (tert-butoxycarbonyl) group and halogen substituents (bromo and fluoro) for further derivatization. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry for creating libraries of compounds.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging the halogenated aromatic structure.
• Peptide Mimetics & PROTACs: Serves as a versatile linker or spacer molecule in the design of peptide analogs and Proteolysis Targeting Chimeras (PROTACs).
• Material Science Research: Employed in the creation of specialty polymers and organic electronic materials due to its aromatic and halogenated properties.
• Chemical Biology Probes: Acts as a precursor for fluorescent tags or affinity probes used in biochemical assays and diagnostic development.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.

Basic Information

Product Name	5-Bromo-3-Fluoro-n-Boc-Benzylamine
CAS No.	1177558-40-5
Molecular Formula	C₁₂H₁₅BrFNO₂
Molecular Weight	304.16 g/mol
Synonyms	1-[(1,1-Dimethylethoxy)carbonyl]-5-bromo-3-fluorobenzylamine; tert-Butyl N-[(5-bromo-3-fluorophenyl)methyl]carbamate; N-Boc-5-Bromo-3-fluorobenzylamine; 5-Bromo-3-fluoro-N-(tert-butoxycarbonyl)benzylamine; Boc-5-Bromo-3-fluoro-benzylamine; (5-Bromo-3-fluorobenzyl)carbamic acid tert-butyl ester; N-(tert-Butoxycarbonyl)-5-bromo-3-fluorobenzylamine
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-Fluoro-n-Boc-Benzylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.