Description

Dextromethorphan n-Oxide is a key chemical intermediate and metabolite of the widely used antitussive agent, dextromethorphan. This compound is of significant interest in pharmaceutical research and development, particularly for studies involving drug metabolism, pharmacokinetics, and the synthesis of novel therapeutic agents. It serves as a critical building block for researchers and manufacturers in the pharmaceutical, fine chemical, and reference standard sectors.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis and research of dextromethorphan-based active pharmaceutical ingredients (APIs) and their derivatives.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical laboratories for the identification and quantification of dextromethorphan metabolites in pharmacokinetic and toxicology studies.
• Pharmacological Research: Employed in preclinical and clinical research to study the metabolic pathways, efficacy, and safety profile of dextromethorphan.
• Impurity Standard: Serves as a certified reference material (CRM) for quality control, ensuring the purity of dextromethorphan APIs by identifying and controlling process-related impurities.
• Chemical Synthesis: Utilized as a specialized reagent in organic synthesis for the development of new chemical entities with potential neurological activity.

Basic Information

Product Name	Dextromethorphan n-Oxide
CAS No.	1177494-18-6
Molecular Formula	C₁₈H₂₅NO₂
Molecular Weight	287.40 g/mol
Synonyms	Dextromethorphan N-Oxide; (+)-3-Methoxy-17-methyl-9α,13α,14α-morphinan N-Oxide; Dextromethorphan N-Oxide Hydrobromide (salt form precursor); DXM N-Oxide; Morphinan-3-ol, 17-methyl-, 3-methoxy-, N-oxide, (9α,13α,14α)-; Dextromethorphan Metabolite; 1,2,3,9,10,10a-Hexahydro-6-methoxy-11-methyl-4H-10,4a-(iminoethano)phenanthren-4-ol N-Oxide
EINECS	Contact for details

Quality Control

Our Dextromethorphan n-Oxide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific client or pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.