Description

7-Hydroxy Coumarin β-D-Glucuronide Methyl Ester is a high-purity biochemical reference standard and synthetic intermediate. This compound is critical for analytical method development and validation in pharmacokinetic and metabolic studies, serving as a key metabolite or conjugate of coumarin derivatives. It is primarily utilized by research institutions, pharmaceutical developers, and contract research organizations (CROs) engaged in drug metabolism and disposition (DMPK) research, bioanalytical assay development, and the synthesis of advanced pharmaceutical intermediates.

Application

• Biochemical Reference Standard: Used as a certified standard for the quantification of coumarin metabolites in biological matrices via HPLC, LC-MS, or GC-MS.
• Drug Metabolism & Pharmacokinetics (DMPK): Serves as a critical metabolite standard in studies investigating the glucuronidation pathway and bioavailability of coumarin-based therapeutics.
• Enzyme Activity Assays: Employed as a substrate or reference compound in assays for UDP-glucuronosyltransferase (UGT) enzyme activity and inhibition studies.
• Pharmaceutical Intermediate: Acts as a protected synthetic precursor in the multi-step synthesis of more complex glucuronidated drug molecules or fluorescent probes.
• Analytical Method Development: Essential for developing and validating robust bioanalytical methods in compliance with FDA and ICH guidelines for clinical and pre-clinical trials.

Basic Information

Product Name	7-Hydroxy Coumarin β-D-Glucuronide Methyl Ester
CAS No.	1176514-11-6
Molecular Formula	C₁₆H₁₈O₁₀
Molecular Weight	370.31 g/mol
Synonyms	7-Hydroxycoumarin glucuronide methyl ester; 7-Hydroxy-2H-1-benzopyran-2-one β-D-glucopyranosiduronic acid methyl ester; Hymecromone glucuronide methyl ester; Methyl (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((7-hydroxy-2-oxo-2H-chromen-4-yl)oxy)tetrahydro-2H-pyran-2-carboxylate; 4-Methylumbelliferone glucuronide methyl ester (related); 7-HC-Gluc-Me; Coumarin-7-yl β-D-glucuronide methyl ester
EINECS	Contact for details

Quality Control

Our 7-Hydroxy Coumarin β-D-Glucuronide Methyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant industry standards, and specifications can be tailored to meet specific project requirements for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.