Description

1-[4-(Trifluoromethyl)Benzyl]-1H-Pyrazole-4-Carboxylic Acid is a high-value, multifunctional heterocyclic building block featuring a pyrazole core substituted with a carboxylic acid group and a trifluoromethylbenzyl moiety. Its molecular architecture makes it a critical intermediate for the synthesis of advanced pharmaceutical compounds and agrochemicals, where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. This compound is essential for researchers and manufacturers in medicinal chemistry and fine chemical synthesis, particularly those developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and anti-inflammatory drug discovery programs.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrazole ring.
• Ligand & Catalyst Development: Used in organometallic chemistry to create specialized ligands for catalysis.
• Material Science Research: Investigated as a monomer or additive for creating polymers with specific thermal or chemical resistance properties.
• Chemical Biology Probes: Employed in the design of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	1-[4-(Trifluoromethyl)Benzyl]-1H-Pyrazole-4-Carboxylic Acid
CAS No.	1174666-17-1
Molecular Formula	C12H9F3N2O2
Molecular Weight	270.21 g/mol
Synonyms	1-[(4-Trifluoromethyl)benzyl]-1H-pyrazole-4-carboxylic acid; 1-(4-(Trifluoromethyl)benzyl)-1H-pyrazole-4-carboxylic acid; 4-Pyrazolecarboxylic acid, 1-[[4-(trifluoromethyl)phenyl]methyl]-; 1H-Pyrazole-4-carboxylic acid, 1-[[4-(trifluoromethyl)phenyl]methyl]-; 1-(4-Trifluoromethyl-benzyl)-1H-pyrazole-4-carboxylic acid; 1174666-17-1; 1-(4-(Trifluoromethyl)benzyl)-1H-pyrazole-4-carboxylate
EINECS	Contact for details

Quality Control

Our production of 1-[4-(Trifluoromethyl)Benzyl]-1H-Pyrazole-4-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting compliance in GMP-aligned synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.