Description

Neomycin Trisulfate Hydrate Deuterated is a stable isotope-labeled analog of the broad-spectrum aminoglycoside antibiotic neomycin. This compound is essential for advanced quantitative mass spectrometry, serving as a critical internal standard to ensure analytical accuracy and reproducibility in pharmacokinetic and metabolomic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug metabolism and residue analysis.

Application

• Quantitative Mass Spectrometry (LC-MS/MS): Used as an internal standard for the precise quantification of neomycin and related compounds in complex biological matrices.
• Pharmacokinetic & Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Veterinary Drug Residue Analysis: Critical for ensuring food safety by monitoring neomycin levels in meat, milk, and other animal-derived products.
• Metabolomics & Biomarker Discovery: Facilitates stable isotope dilution methods for the identification and quantification of microbial or metabolic pathway products.
• Method Development & Validation: Provides a reference point for developing and validating robust, regulatory-compliant analytical methods (e.g., for FDA, EMA).
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay verification for antibiotic production.

Basic Information

Product Name	Neomycin Trisulfate Hydrate Deuterated
CAS No.	1173840-30-6
Molecular Formula	C₂₃H₄₆D₁₆N₆O₁₃ • 3H₂SO₄ • xH₂O
Molecular Weight	Contact for details
Synonyms	Neomycin-d16 Trisulfate Hydrate; Deuterated Neomycin Sulfate; [²H₁₆]-Neomycin Trisulfate; Neomycin (sulfate) deuterated; Stable Isotope Labeled Neomycin Sulfate; Neomycin-d16; Internal Standard for Neomycin; 4-O-(2,6-Diamino-2,6-dideoxy-α-D-glucopyranosyl)-2-deoxy-D-streptamine-d16 sulfate
EINECS	Contact for details

Quality Control

Our Neomycin Trisulfate Hydrate Deuterated is manufactured under strict quality systems to ensure high isotopic purity and chemical integrity, critical for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity (by HPLC), and residual solvent content. We adhere to relevant industry guidelines for stable isotope-labeled compounds to guarantee consistency and reliability for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccants or inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Isotopic Purity (Atom % D)	≥ 98%
Chemical Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 10.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.