Description

Fluoxetine-D5 Solution is a deuterated internal standard of the widely prescribed antidepressant, fluoxetine, specifically designed for analytical applications. This high-purity, isotopically labeled compound is essential for achieving precise and reliable quantification in complex matrices. It is primarily utilized by pharmaceutical research laboratories, contract research organizations (CROs), and forensic toxicology units engaged in method development, pharmacokinetic studies, and drug metabolism research.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a critical internal standard for the accurate quantification of fluoxetine and its metabolites in biological samples (plasma, serum, urine).
• Pharmacokinetic and Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Forensic and Clinical Toxicology: Used in confirmatory testing and monitoring of fluoxetine levels for therapeutic drug monitoring (TDM) or forensic investigations.
• Drug Metabolism Research: Facilitates the identification and quantification of fluoxetine metabolites in in vitro and in vivo studies.
• Method Development and Validation: A key component in developing and validating robust, regulatory-compliant analytical methods (following FDA, EMA guidelines).
• Quality Control in Pharmaceutical Manufacturing: Can be employed in impurity profiling and stability-indicating assays for fluoxetine active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	Fluoxetine-D5 Solution
CAS No.	1173147-79-9
Molecular Formula	C17H13D5F3NO
Molecular Weight	314.35 g/mol
Synonyms	N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine-d5; (±)-Fluoxetine-d5; N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine-d5; Prozac-d5 (deuterated); Fluoxetine (phenyl-d5); 3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine-d5
EINECS	Contact for details

Quality Control

Our Fluoxetine-D5 Solution is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at the recommended temperature as specified on the label or COA (typically 2-8°C or -20°C for long-term storage). Due to its highly volatile nature in solution, ensure containers are securely sealed and handled in a well-ventilated area to prevent solvent evaporation and concentration changes.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 98.0% (Fluoxetine-D5)
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 99.0%
Solvent	Methanol, Acetonitrile, or as specified
Concentration	100 µg/mL, 1.0 mg/mL, or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.