Description

1-(2,2-Difluoroethyl)-1H-Pyrazole is a specialized fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity and physicochemical properties imparted by the difluoroethyl group, making it a critical intermediate for developing novel compounds. This product is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create new active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorine motifs to modulate potency, lipophilicity, and metabolic stability.
• Agrochemical Synthesis: Serves as a building block for novel herbicides, fungicides, and insecticides, leveraging fluorine's ability to enhance biological activity and environmental persistence.
• Material Science Research: Used in the development of advanced polymers, liquid crystals, and electronic materials where fluorinated pyrazole units can alter thermal and electronic properties.
• Chemical Biology & Probe Development: Employed as a scaffold for creating molecular probes and tags used in bioimaging and diagnostic assays.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses serving clients in life sciences and specialty chemicals.

Basic Information

Product Name	1-(2,2-Difluoroethyl)-1H-Pyrazole
CAS No.	1173030-07-3
Molecular Formula	C5H6F2N2
Molecular Weight	132.11 g/mol
Synonyms	1-(2,2-Difluoroethyl)-1H-pyrazole; 1H-Pyrazole, 1-(2,2-difluoroethyl)-; 1-(Difluoroethyl)pyrazole; 2,2-Difluoroethylpyrazole; N-(2,2-Difluoroethyl)pyrazole; Pyrazole, 1-(2,2-difluoroethyl)-; 1173030-07-3
EINECS	Contact for details

Quality Control

Our production of 1-(2,2-Difluoroethyl)-1H-Pyrazole adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, GC for residual solvents, and NMR/IR for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with customer requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.