Description

Bufuralol-(T-Butyl-D9) Hydrochloride is a high-purity, isotopically labeled internal standard critical for advanced analytical quantification. This deuterated compound is essential for ensuring accuracy and reliability in sensitive mass spectrometry-based analyses, providing superior signal differentiation from the non-labeled analyte. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in method development, pharmacokinetic studies, and regulatory bioanalysis.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound in the quantitative bioanalysis of bufuralol and related metabolites in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Pharmaceutical Impurity Profiling: Used in method development to identify and quantify process-related impurities and degradation products in active pharmaceutical ingredient (API) batches.
• Forensic and Clinical Toxicology: Supports accurate quantification in assays designed for therapeutic drug monitoring or forensic substance identification.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy analytical techniques that require an isotopically labeled analog for optimal precision.

Basic Information

Product Name	Bufuralol-(T-Butyl-D9) Hydrochloride
CAS No.	1173023-51-2
Molecular Formula	C16H14D9ClNO2 • HCl
Molecular Weight	Contact for details
Synonyms	1-(2-(1,1-Dimethylethyl-d9)amino)-1-hydroxyethyl)-7-ethyl-2,3-dihydro-1-benzofuran Hydrochloride; Bufuralol tert-Butyl-d9 Hydrochloride; Deuterated Bufuralol Hydrochloride; Bufuralol (tert-butyl-d9) HCl; Bufuralol-d9 (tert-butyl labeled) Hydrochloride; Bufuralol Internal Standard (d9); [2H9]-Bufuralol Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Bufuralol-(T-Butyl-D9) Hydrochloride is manufactured and analyzed under strict quality management systems to ensure the highest standards of isotopic purity and chemical integrity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with research and analytical standards. Certificates of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.