Description

5-Acetylamino-6-Amino-3-Methyluracil-[13C4,15N3] (Aamu) is a high-purity, stable isotope-labeled uracil derivative, specifically designed for advanced analytical and research applications. This compound is essential for use as an internal standard in quantitative mass spectrometry, enabling unparalleled accuracy and precision in pharmacokinetic, metabolic, and proteomic studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in drug discovery and development.

Application

• Quantitative Mass Spectrometry (LC-MS/MS): Serves as a stable isotope-labeled internal standard for the precise quantification of uracil derivatives and related metabolites in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of new chemical entities.
• Proteomics and Biomarker Discovery: Enables accurate relative and absolute quantification of proteins and peptides in isotope-coded affinity tag (ICAT) and other labeling techniques.
• Pharmaceutical Reference Standard: Provides a certified reference material for method development, validation, and quality control in analytical laboratories.
• Nucleic Acid Research: Acts as a labeled precursor or probe in studies involving pyrimidine metabolism, DNA/RNA synthesis, and related biochemical pathways.
• Clinical Diagnostics: Supports the development of highly sensitive and specific diagnostic assays for metabolic disorders or therapeutic drug monitoring.

Basic Information

Product Name	5-Acetylamino-6-Amino-3-Methyluracil-[13C4,15N3] (Aamu)
CAS No.	1173022-65-5
Molecular Formula	C713C4H11N215N3O3
Molecular Weight	~218.13 g/mol (labeled)
Synonyms	AAU-[13C4,15N3]; 5-Acetamido-6-amino-3-methyluracil-[13C4,15N3]; 6-Amino-5-acetylamino-3-methyluracil-[13C4,15N3]; 3-Methyl-5-acetylamino-6-aminouracil-[13C4,15N3]; 5-(Acetylamino)-6-amino-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione-[13C4,15N3]; AAMU-[13C4,15N3]; Stable Isotope Labeled AAMU; [13C4,15N3]-AAMU
EINECS	Contact for details

Quality Control

Every batch of 5-Acetylamino-6-Amino-3-Methyluracil-[13C4,15N3] is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity verified by advanced techniques including NMR, HPLC, and high-resolution mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, isotopic enrichment, and other critical specifications to ensure compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product at 2-8°C under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 99 atom % 15N
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.