Description

Mebendazole-D3 is a deuterium-labeled analog of the broad-spectrum anthelmintic drug Mebendazole, specifically identified by CAS No. 1173021-87-8. This stable isotope-labeled compound is an essential internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and regulatory compliance for antiparasitic agents.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative reference standard in Liquid Chromatography-Tandem Mass Spectrometry for the analysis of Mebendazole and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) studies.
• Clinical Research: Supports the development and validation of robust analytical methods for clinical trial sample analysis.
• Forensic and Anti-Doping Analysis: Used in confirmatory testing protocols where high specificity and accuracy are mandated.
• Pharmaceutical Quality Control: Can be employed in method development for impurity profiling and stability testing of Mebendazole formulations.
• Reference Material Manufacturing: Serves as a certified component in the production of accredited reference materials for laboratories.

Basic Information

Product Name	Mebendazole-D3
CAS No.	1173021-87-8
Molecular Formula	C16H10D3N3O3
Molecular Weight	298.32 g/mol
Synonyms	(5-Benzoyl-1H-benzimidazol-2-yl)carbamic acid methyl ester-d3; Mebendazole (methyl-d3); Mebendazole-methyl-d3; 5-Benzoyl-2-benzimidazolecarbamic acid methyl ester-d3; Vermox-d3; NSC-311858-d3; Methyl 5-benzoyl-2-benzimidazolecarbamate-d3; Antiox-d3
EINECS	Contact for details

Quality Control

Our Mebendazole-D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and Mass Spectrometry for isotopic enrichment confirmation and HPLC for chemical and isotopic purity. We provide Certificates of Analysis (COA) detailing batch-specific results for identity, assay, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.