Description

Fluoxetine-D5 Hydrochloride is a deuterated internal standard of the widely prescribed antidepressant, fluoxetine hydrochloride, specifically designed for analytical and research applications. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry and pharmacokinetic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities for method development, drug metabolism research, and bioanalytical assays.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the precise quantification of fluoxetine and its metabolites in biological matrices (e.g., plasma, serum, urine).
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic & Clinical Toxicology: Used in analytical methods for the confirmation and quantification of fluoxetine in forensic investigations and therapeutic drug monitoring (TDM).
• Pharmaceutical Quality Control: Applied in the development and validation of analytical methods for drug substance and finished product testing.
• Reference Standard: Acts as a certified reference material (CRM) for calibrating instruments and validating analytical procedures in compliance with GLP and GMP guidelines.
• Stable Isotope Labeling Research: Used in mechanistic studies to elucidate metabolic pathways and degradation products.

Basic Information

Product Name	Fluoxetine-D5 Hydrochloride
CAS No.	1173020-43-3
Molecular Formula	C17H13D5ClF3NO
Molecular Weight	345.79 g/mol
Synonyms	N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine-D5 hydrochloride; (±)-Fluoxetine-D5 hydrochloride; (RS)-Fluoxetine-D5 hydrochloride; Prozac-D5 hydrochloride; N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine-D5 hydrochloride; 3-(p-Trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine-D5 hydrochloride
EINECS	Contact for details

Quality Control

Our Fluoxetine-D5 Hydrochloride is manufactured under strict quality systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic purity (by MS), and other critical parameters. We support compliance with GLP and GMP guidelines for research and pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.