Description

Semicarbazide-13C,15N2 Hydrochloride is a stable isotope-labeled derivative of semicarbazide hydrochloride, where the carbon-13 and nitrogen-15 isotopes provide unique molecular tracers for advanced analytical research. This compound is essential for precise quantification and metabolic pathway tracing in complex biological and chemical systems. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, agrochemical, and environmental science sectors who require high-fidelity internal standards for mass spectrometry and NMR studies.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical quantitative reference in LC-MS/MS and GC-MS methods for the accurate detection of semicarbazide and related hydrazine compounds.
• Metabolic Pathway Tracing: Used in pharmacokinetic and drug metabolism studies to track the fate of active pharmaceutical ingredients and their metabolites.
• Food Safety & Environmental Analysis: Enables precise monitoring of nitrofurazone antibiotic residues (which metabolize to semicarbazide) in food products like honey, poultry, and seafood, as well as in environmental samples.
• NMR Spectroscopy Studies: Provides non-radioactive, stable isotopic labels for structural elucidation and dynamic studies of molecular interactions.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants in drug substances and products.
• Chemical Synthesis Research: Acts as a labeled building block for synthesizing more complex isotopically labeled compounds for research purposes.

Basic Information

Product Name	Semicarbazide-13C,15N2 Hydrochloride
CAS No.	1173020-16-0
Molecular Formula	13CH615N3O • HCl
Molecular Weight	112.53 g/mol (for labeled form)
Synonyms	Aminourea-13C,15N2 Hydrochloride; Carbamylhydrazine-13C,15N2 Hydrochloride; Hydrazinecarboxamide-13C,15N2 Hydrochloride; [13C,15N2]-Semicarbazide Hydrochloride; Isotopically Labeled Semicarbazide HCl; SEM-13C,15N2 HCl; Stable Isotope-Labeled Semicarbazide
EINECS	Contact for details

Quality Control

Every batch of Semicarbazide-13C,15N2 Hydrochloride is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR and MS to confirm isotopic enrichment and positional labeling. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and specific analytical results. Our quality commitment ensures reliability for your most sensitive research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 99 atom % 15N
Assay (HPLC)	≥ 98.0%
Chemical Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.