Description

Triphosgene-13C3 is a stable, isotopically labeled analog of triphosgene, where all three carbonyl carbon atoms are replaced with the carbon-13 isotope (CAS NO 1173019-90-3). This labeled compound is essential for advanced research and development, providing a non-radioactive tracer for mechanistic studies, metabolic pathway analysis, and internal standard applications in mass spectrometry. It is a critical reagent for pharmaceutical, agrochemical, and academic laboratories engaged in synthesizing and analyzing labeled compounds, particularly in the development of new active ingredients where tracking molecular fate is paramount.

Application

• Pharmaceutical R&D: Used as a carbon-13 labeled phosgene equivalent for synthesizing isotopically labeled drug candidates, metabolites, and internal standards for bioanalytical assays (LC-MS/MS).
• Metabolic Studies: Serves as a tracer molecule to investigate the metabolic pathways and degradation products of compounds containing carbonyl or chloroformate groups.
• Mechanistic Organic Chemistry: Employed to elucidate reaction mechanisms, particularly in carbonylations, chloroformylations, and the formation of carbonates, ureas, and isocyanates.
• Agrochemical Research: Utilized in the synthesis of labeled pesticides, herbicides, and their metabolites for environmental fate and residue analysis studies.
• Analytical Chemistry: Acts as a high-purity internal standard for the accurate quantification of triphosgene or related compounds via mass spectrometry, improving analytical precision.
• Material Science: Applied in the synthesis of specialty polymers and advanced materials where isotopic labeling is required to study structure-property relationships or degradation mechanisms.

Basic Information

Product Name	Triphosgene-13C3
CAS No.	1173019-90-3
Molecular Formula	13C3Cl6O3
Molecular Weight	302.77 (based on 13C)
Synonyms	Bis(trichloromethyl) carbonate-13C3; Carbonochloridic acid, trichloromethyl ester-13C3; Trichloromethyl chloroformate-13C3 dimer; BTC-13C3; Triphosgene-13C3; [13C3]-Triphosgene; 1,3,5-Trioxane-2,4,6-trione, 1,3,5-trichloro- (13C3); Isotopically labeled triphosgene
EINECS	Contact for details

Quality Control

Our Triphosgene-13C3 is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity, meeting the stringent requirements of research and analytical applications. Each batch undergoes rigorous quality testing, including analysis by NMR, HPLC, and mass spectrometry, to confirm isotopic enrichment (typically >99 atom % 13C), chemical purity, and identity. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
13C Isotopic Enrichment	≥ 99 atom %
Assay (HPLC)	≥ 98.0%
Chemical Purity (by GC)	≥ 99.0%
Melting Point	78 - 82 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.