Description

Probucol-[13C3] CAS NO 1173019-29-8 is a stable isotope-labeled analog of the cholesterol-lowering drug probucol, where three carbon atoms are replaced with the Carbon-13 (13C) isotope. This compound is an essential internal standard for the accurate quantification and pharmacokinetic profiling of probucol in biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and bioanalytical studies. The use of this isotopically labeled standard ensures superior accuracy, precision, and reliability in quantitative mass spectrometry, supporting critical phases of drug development and regulatory compliance.

Application

• Internal Standard for Bioanalysis: Serves as a critical internal standard in the quantitative LC-MS/MS analysis of probucol in plasma, serum, and other biological fluids for pharmacokinetic (PK) and toxicokinetic (TK) studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in mass spectrometry-based assays to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of probucol.
• Clinical Trial Support: Enables precise and reliable measurement of drug concentrations in samples from clinical trials, ensuring data integrity for regulatory submissions.
• Reference Material for Method Development: Acts as a certified reference material for developing, validating, and troubleshooting sensitive bioanalytical methods in compliance with GLP/GCP guidelines.
• Stable Isotope Dilution Assays: Employed in stable isotope dilution mass spectrometry (SID-MS) to achieve the highest level of accuracy by correcting for analyte loss during sample preparation and instrument variability.
• Pharmaceutical Quality Control: Can be utilized in impurity profiling and stability-indicating methods for probucol-based pharmaceutical formulations.

Basic Information

Product Name	Probucol-[13C3]
CAS No.	1173019-29-8
Molecular Formula	C31H48O2S2 (with three 13C atoms)
Molecular Weight	~519.85 g/mol (exact mass depends on labeling position)
Synonyms	4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol]-[13C3]; 13C3-Labeled Probucol; Probucol (13C3); Isotopically Labeled Probucol; Biphenabid-[13C3]; Lesterol-[13C3]; Lorelco-[13C3]; [13C3]-4,4'-(Isopropylidenedithio)bis(2,6-di-tert-butylphenol)
EINECS	Contact for details

Quality Control

Our Probucol-[13C3] is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive mass spectrometry applications. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity, NMR and MS for structural and isotopic confirmation, and residual solvent analysis. Certificates of Analysis (COA) are provided, detailing the isotopic enrichment (typically >99% 13C atom percent), chemical purity, and specific analytical data. Our quality commitment aligns with the standards expected in pharmaceutical R&D and bioanalytical testing.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure and isotopic pattern
Purity (HPLC)	≥98.0%
Isotopic Purity (13C)	≥99 atom % 13C
Isotopic Enrichment	≥99% (by MS)
Chemical Purity	≥98%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.