Description

(2E)-4,4,4-Trifluoro-n-Methoxy-n-Methyl-2-Butenamide is a high-purity fluorinated building block characterized by its unique α,β-unsaturated amide structure. This compound is valued for its role as a key synthetic intermediate in advanced organic synthesis, enabling the introduction of a trifluoromethyl group and reactive olefin functionality. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting metabolic and central nervous system disorders.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of specialty polymers and advanced materials with specific surface properties.
• Chemical Biology Probe Development: Employed in medicinal chemistry for creating tool compounds and probes to study enzyme mechanisms and protein-ligand interactions.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research focused on developing new methodologies for incorporating fluorine into complex molecules.

Basic Information

Product Name	(2E)-4,4,4-Trifluoro-n-Methoxy-n-Methyl-2-Butenamide
CAS No.	1172603-97-2
Molecular Formula	C7H8F3NO2
Molecular Weight	195.14 g/mol
Synonyms	4,4,4-Trifluoro-3-(methoxy(methyl)amino)-2-butenoic acid amide; (E)-4,4,4-Trifluoro-3-(methoxy(methyl)amino)but-2-enamide; 4,4,4-Trifluoro-N-methoxy-N-methyl-2-butenamide; (2E)-4,4,4-Trifluoro-3-(methoxy(methyl)amino)but-2-enamide; N-Methoxy-N-methyl-4,4,4-trifluoro-2-butenamide; TFMBA; Trifluoromethyl butenamide derivative
EINECS	Contact for details

Quality Control

Our (2E)-4,4,4-Trifluoro-n-Methoxy-n-Methyl-2-Butenamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.