Description

n-(2,2,2-Trifluoroethyl)Piperidine-4-Carboxamide Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine carboxamide core and trifluoroethyl substituent. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in central nervous system (CNS) and metabolic disorder research.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize drug candidate potency and selectivity.
• Protease Inhibitor Development: A potential building block for compounds targeting various protease enzymes.
• Kinase Inhibitor Synthesis: Employed in the creation of novel kinase inhibitors for oncology and inflammatory disease applications.
• CNS Drug Discovery: Utilized in research programs aimed at neurological and psychiatric disorders due to the piperidine moiety.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials.
• Chemical Reference Standard: Provides a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	n-(2,2,2-Trifluoroethyl)Piperidine-4-Carboxamide Hydrochloride
CAS No.	1172528-88-9
Molecular Formula	C8H14ClF3N2O
Molecular Weight	246.66 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)-4-piperidinecarboxamide Hydrochloride; 4-Piperidinecarboxamide, N-(2,2,2-trifluoroethyl)-, hydrochloride; N-(2,2,2-Trifluoroethyl)isonipecotamide Hydrochloride; TFEPCA HCl; 1172528-88-9; UNII-8K8V1169QN; 8K8V1169QN; Isonipecotamide, N-(2,2,2-trifluoroethyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Our n-(2,2,2-Trifluoroethyl)Piperidine-4-Carboxamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material is suitable for advanced research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.