Description

(S)-n-Fmoc-α-Methyl-2-Fluorophenylalanine, 98% Ee, 98% is a high-purity, non-natural amino acid derivative featuring a chiral α-methyl group and a 2-fluorophenyl side chain, protected by an Fmoc group. This compound is critical for the synthesis of peptide-based pharmaceuticals and research tools, where its structural modifications enhance metabolic stability and receptor binding affinity. It is an essential building block for medicinal chemists and peptide synthesis specialists in pharmaceutical R&D and biotechnology.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected building block for the automated synthesis of complex peptides.
• Medicinal Chemistry & Drug Discovery: Used to incorporate a constrained, fluorinated phenylalanine analog into peptide leads to improve potency, selectivity, and pharmacokinetic properties.
• Protease Inhibitor Development: The α-methyl group provides resistance to enzymatic degradation, making it valuable for creating stable protease inhibitors.
• Peptidomimetic Research: Serves as a core scaffold for designing molecules that mimic the structure and function of natural peptides.
• Chemical Biology Probes: Utilized in the synthesis of labeled or modified peptides for studying protein-protein interactions and cellular pathways.
• API Intermediate Manufacturing: An advanced intermediate in the production of active pharmaceutical ingredients (APIs) for therapeutic peptides.

Basic Information

Product Name	(S)-n-Fmoc-α-Methyl-2-Fluorophenylalanine, 98% Ee, 98%
CAS No.	1172127-44-4
Molecular Formula	C26H24FNO4
Molecular Weight	433.47 g/mol
Synonyms	Fmoc-(S)-α-Me-2-F-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-fluorophenyl)-D-alanine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-3-(2-fluorophenyl)propanoic acid; Fmoc-D-α-methyl-2-fluorophenylalanine; N-Fmoc-3-(2-fluorophenyl)-D-alanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methyl-3-(2-fluorophenyl)propanoic acid; BOC Sciences Brand Name: BBL-BB-013077
EINECS	Contact for details

Quality Control

Every batch of our (S)-n-Fmoc-α-Methyl-2-Fluorophenylalanine is produced and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.