Description

n-(2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridin-7-Yl)Pivalamide is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating a furopyridine core and a tert-butyldimethylsilyl (TBDMS) protecting group. This compound is of significant value in medicinal chemistry research and development, serving as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents, particularly those targeting complex biological pathways.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis Building Block: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex molecules for clients.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry, protective group strategies, and new synthetic methodologies.

Basic Information

Product Name	n-(2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridin-7-Yl)Pivalamide
CAS No.	1171920-37-8
Molecular Formula	C20H30N2O3Si
Molecular Weight	374.56 g/mol
Synonyms	7-Pivalamido-2-((tert-butyldimethylsilyloxy)methyl)furo[3,2-b]pyridine; N-[2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]furo[3,2-b]pyridin-7-yl]-2,2-dimethylpropanamide; Pivalamide, N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]furo[3,2-b]pyridin-7-yl]-; TBDMS-protected furopyridine pivalamide; 1171920-37-8
EINECS	Contact for details

Quality Control

Our n-(2-((tert-Butyldimethylsilyloxy)Methyl)-Furo[3,2-B]Pyridin-7-Yl)Pivalamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.