Description

5-Bromo-1,1-Difluoro-2,3-Dihydro-1H-Indene is a high-value, halogenated indane derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluoro and bromo groups can enhance biological activity and environmental stability.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its rigid, halogenated aromatic core.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Negishi, Stille couplings) for constructing biaryl and complex aromatic systems.
• Fluorine Chemistry Research: An important compound for studying the effects of gem-difluoro substitution on the reactivity and physicochemical properties of organic molecules.
• Ligand and Catalyst Development: Used as a backbone for creating novel chiral or bidentate ligands for asymmetric catalysis.

Basic Information

Product Name	5-Bromo-1,1-Difluoro-2,3-Dihydro-1H-Indene
CAS No.	1171916-82-7
Molecular Formula	C9H7BrF2
Molecular Weight	233.05 g/mol
Synonyms	5-Bromo-1,1-difluoroindane; 1,1-Difluoro-5-bromo-2,3-dihydro-1H-indene; 5-Bromo-1,1-difluoroindan; 2,3-Dihydro-5-bromo-1,1-difluoro-1H-indene; 1171916-82-7; 5-Bromo-α,α-difluoroindane
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-1,1-Difluoro-2,3-Dihydro-1H-Indene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality protocols are designed to support compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.