Description

X-Pphos is a specialized, high-performance phosphine ligand widely used in modern synthetic chemistry. Its primary value lies in enabling highly efficient and selective cross-coupling reactions, which are critical for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require robust catalytic systems for challenging transformations.

Application

X-Pphos is a versatile ligand with applications across various high-value chemical synthesis fields:

• Pharmaceutical Intermediate Synthesis: Catalyzes key carbon-carbon and carbon-heteroatom bond-forming reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig amination) for active pharmaceutical ingredients (APIs).
• Agrochemical Production: Used in the synthesis of complex, bioactive molecules for crop protection agents and herbicides.
• Fine Chemical Manufacturing: Facilitates the production of specialty chemicals, flavors, fragrances, and electronic materials.
• Academic & Industrial R&D: Serves as a critical tool for method development and exploring new catalytic processes in both academic and industrial research laboratories.
• Polymer Chemistry: Employed in catalytic systems for the synthesis of specialized polymers and functional materials.

Basic Information

Product Name	X-Pphos
CAS No.	1171461-61-2
Molecular Formula	C31H43OP2
Molecular Weight	478.62 g/mol
Synonyms	2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl; XPhos; XPhos Ligand; X-Phos; 2-Dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl; XPhos Pd G3; DavePhos-type ligand; Biarylphosphine ligand
EINECS	Contact for details

Quality Control

Our X-Pphos is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, which is critical for catalytic performance. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity (by HPLC/NMR), residual solvent content, and moisture levels. Our quality management system is designed to meet the stringent requirements of GMP and ISO standards for advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (argon or nitrogen) is recommended. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.