Description

Cyclizine D3 CAS NO 1170155-67-5 is a deuterium-labeled isotopologue of the antihistamine and antiemetic drug Cyclizine, where three hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug development and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the analysis of Cyclizine in biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables precise tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profile in preclinical and clinical studies.
• Bioequivalence and Bioavailability Studies: Critical for ensuring method accuracy in studies required for generic drug approval by regulatory authorities such as the FDA and EMA.
• Forensic and Clinical Toxicology: Used in analytical assays to accurately quantify Cyclizine levels in forensic investigations or therapeutic drug monitoring.
• Pharmaceutical Quality Control: Supports analytical method development and validation for impurity profiling and stability testing of drug products containing Cyclizine.

Basic Information

Product Name	Cyclizine D3
CAS No.	1170155-67-5
Molecular Formula	C18H19D3N2
Molecular Weight	269.40 g/mol
Synonyms	1-(Diphenylmethyl)-4-methylpiperazine-d3; 1-Benzhydryl-4-methylpiperazine-d3; Cyclizine-d3; Deuterated Cyclizine; Cyclizine (methyl-d3); Cyclizine Internal Standard; [2H3]-Cyclizine; Marzine-d3
EINECS	Contact for details

Quality Control

Our Cyclizine D3 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is fully characterized and undergoes rigorous testing, including NMR and mass spectrometry for isotopic enrichment verification and HPLC for chemical purity assessment. A comprehensive Certificate of Analysis (COA) is supplied with each product, detailing batch-specific results for identity, purity (by HPLC), isotopic purity, and residual solvents. Our quality commitment supports compliance with GMP/GLP principles for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or Certificate of Analysis. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.