Description

tert-Butyl 4-(Cyano(Phenyl)Methylene)Piperidine-1-Carboxylate is a versatile and high-value synthetic intermediate characterized by its piperidine core and cyano-methylene functional group. This compound matters for its critical role in facilitating complex molecular transformations, particularly in the construction of nitrogen-containing heterocycles and pharmacologically active scaffolds. Pharmaceutical R&D and fine chemical synthesis professionals need it for developing new active pharmaceutical ingredients (APIs) and advanced agrochemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel piperidine-based drug candidates targeting central nervous system (CNS) disorders, analgesics, and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, leveraging its structural complexity for enhanced biological activity.
• Organic Synthesis & Method Development: Serves as a pivotal substrate in palladium-catalyzed cross-coupling reactions, Michael additions, and other advanced organic transformations for academic and industrial research.
• Ligand & Catalyst Precursor: Utilized in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	tert-Butyl 4-(Cyano(Phenyl)Methylene)Piperidine-1-Carboxylate
CAS No.	1170054-42-8
Molecular Formula	C18H22N2O2
Molecular Weight	298.38 g/mol
Synonyms	1-Boc-4-[(cyano)(phenyl)methylene]piperidine; 1-(tert-Butoxycarbonyl)-4-[(cyano)(phenyl)methylene]piperidine; tert-Butyl 4-[(cyano)(phenyl)methylidene]piperidine-1-carboxylate; 4-(Cyano(phenyl)methylene)piperidine-1-carboxylic acid tert-butyl ester; 1-Boc-4-(cyanobenzylidene)piperidine; 4-(Cyanobenzylidene)piperidine-1-carboxylic acid tert-butyl ester; Boc-4-(cyanobenzylidene)piperidine; 1170054-42-8
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Cyano(Phenyl)Methylene)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent chemical identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.