Description

1-Fluoro-3-Iodo-5-Methoxy-Benzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its unique reactivity profile, where the fluorine and iodine substituents offer orthogonal sites for selective functionalization via cross-coupling and nucleophilic aromatic substitution reactions. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures, including active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic core.
• Cross-Coupling Reactions: The iodine moiety is an excellent substrate for Suzuki, Stille, and Sonogashira cross-coupling reactions to form biaryl systems.
• Fluorine Chemistry Studies: Used as a model compound for investigating the influence of fluorine atoms on aromatic system reactivity and physical properties.

Basic Information

Product Name	1-Fluoro-3-Iodo-5-Methoxy-Benzene
CAS No.	1167056-58-7
Molecular Formula	C7H6FIO
Molecular Weight	252.03 g/mol
Synonyms	3-Fluoro-5-Iodoanisole; 5-Fluoro-3-Iodoanisole; 1-Fluoro-3-iodo-5-methoxybenzene; 3-Iodo-5-fluoroanisole; Benzene, 1-fluoro-3-iodo-5-methoxy-; 5-Methoxy-3-iodofluorobenzene; 3-Fluoro-5-methoxyiodobenzene; m-Fluoro-m'-iodoanisole
EINECS	Contact for details

Quality Control

Our 1-Fluoro-3-Iodo-5-Methoxy-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and process development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.