Description

2-(4-Chloro-3,5-Difluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, active ingredient synthesis, and organic electronic development.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing a difluorinated biphenyl core.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that leverage its specific halogenated aryl structure.
• Material Science: Serves as a monomer or building block for creating organic semiconductors, liquid crystals, and polymers with tailored electronic properties.
• Cross-Coupling Reactions: A versatile reagent for Suzuki-Miyaura cross-coupling to introduce the 4-chloro-3,5-difluorophenyl moiety into target molecules.
• Chemical Research & Development: An invaluable tool for medicinal chemists and process chemists in lead optimization and route scouting.
• Ligand Synthesis: Can be utilized to prepare sophisticated ligands for catalysis.

Basic Information

Product Name	2-(4-Chloro-3,5-Difluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1165935-96-5
Molecular Formula	C12H15BClF2O2
Molecular Weight	272.51 g/mol
Synonyms	4-Chloro-3,5-difluorophenylboronic acid pinacol ester; (4-Chloro-3,5-difluorophenyl)boronic acid pinacol ester; 2-(4-Chloro-3,5-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Chloro-3,5-difluorobenzene-1-boronic acid pinacol ester; Pinacol (4-chloro-3,5-difluorophenyl)boronate; 1165935-96-5; 4-Chloro-3,5-difluorophenyl-Bpin
EINECS	Contact for details

Quality Control

Our 2-(4-Chloro-3,5-Difluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.