Description

n-[(1R)-2'-Amino-4,4',6,6'-Tetrakis(trifluoromethyl)[1,1'-biphenyl]-2-yl]-P,p-diphenyl-phosphinous amide is a sophisticated, chiral organophosphorus compound featuring a biphenyl core heavily substituted with electron-withdrawing trifluoromethyl groups. This unique structure makes it a highly valuable ligand precursor or intermediate in advanced catalytic systems and asymmetric synthesis. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for developing novel synthetic routes to complex, fluorinated active ingredients.

Application

• Asymmetric Catalysis: Serves as a precursor for chiral phosphine or phosphoramidite ligands used in transition metal-catalyzed reactions like hydrogenation, cross-coupling, and hydroformylation.
• Pharmaceutical Intermediate: Key building block in the synthesis of fluorinated drug candidates, leveraging the metabolic stability and lipophilicity imparted by the CF3 groups.
• Agrochemical Research: Used in the development of novel, fluorinated pesticides and herbicides where the specific stereochemistry can influence biological activity.
• Material Science: Potential monomer or additive for creating specialty polymers with unique electronic or surface properties.
• Academic & R&D: A valuable tool for studying structure-activity relationships (SAR) and developing new methodologies in organofluorine and organophosphorus chemistry.

Basic Information

Product Name	n-[(1R)-2'-Amino-4,4',6,6'-Tetrakis(trifluoromethyl)[1,1'-biphenyl]-2-yl]-P,p-diphenyl-phosphinous amide
CAS No.	1165709-81-8
Molecular Formula	C32H19F12N2P
Molecular Weight	690.47 g/mol
Synonyms	(R)-N-(2'-Amino-4,4',6,6'-tetrakis(trifluoromethyl)-[1,1'-biphenyl]-2-yl)-P,P-diphenylphosphinous amide; (1R)-N-[2'-Amino-4,4',6,6'-tetrakis(trifluoromethyl)biphenyl-2-yl]-P,P-diphenylphosphinous amide; BINOL-derived chiral phosphoramidite precursor; Chiral biphenyl phosphinous amide ligand; ATF-BIPHOS-amine derivative
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced and analyzed under strict quality protocols. We employ advanced analytical techniques including HPLC, GC, NMR (¹H, ¹⁹F, ³¹P), and chiral analysis to ensure identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality system is designed to support cGMP requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is sensitive to light and may be incompatible with strong bases and fluorides. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.