Description

2-(4-Difluoromethoxy-3-Fluorophenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. This compound matters as a critical intermediate in cross-coupling reactions, enabling the efficient construction of complex fluorinated aromatic systems. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing new active ingredients and functional molecules with tailored properties.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex biaryl structures, particularly those containing difluoromethoxy and fluorine substituents.
• Pharmaceutical Intermediate: Used in the research and development of novel active pharmaceutical ingredients (APIs), especially for targets requiring specific fluorination patterns to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Serves as a building block for creating new herbicides, fungicides, and insecticides where the difluoromethoxy group can enhance biological activity and environmental profile.
• Materials Science Research: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs or semiconductors, where fluorinated aromatic units improve charge transport and stability.
• Chemical Biology & Probe Development: Useful for creating fluorinated molecular probes and tags for imaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis services targeting fluorinated fine chemicals and specialty compounds.

Basic Information

Product Name	2-(4-Difluoromethoxy-3-Fluorophenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane
CAS No.	1162262-35-2
Molecular Formula	C₁₃H₁₆BF₃O₃
Molecular Weight	288.07 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-[3-fluoro-4-(difluoromethoxy)phenyl]-1,3,2-dioxaborolane; 2-(3-Fluoro-4-(difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (3-Fluoro-4-(difluoromethoxy)phenyl)boronate; (3-Fluoro-4-(difluoromethoxy)phenyl)boronic acid pinacol ester; 4-(Difluoromethoxy)-3-fluorophenylboronic acid pinacol ester; CAS 1162262-35-2; B-[3-Fluoro-4-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
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Quality Control

Our 2-(4-Difluoromethoxy-3-Fluorophenyl)-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹⁹F, ¹¹B), and GC/MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided to guarantee the material meets the stringent requirements for research and process development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the product should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged manipulations and stored with appropriate desiccants. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.