Description

3,4-Difluoro-5-Ethoxyphenylboronic Acid is a high-value, multi-functional boronic acid derivative used as a key synthetic building block in advanced organic chemistry. Its molecular structure, featuring both fluorine and ethoxy substituents, makes it a critical reagent for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, particularly for Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), especially in the development of fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoroethoxy phenyl moiety can enhance biological activity and environmental stability.
• Material Science & OLED Development: Serves as a precursor for creating advanced organic electronic materials, including charge-transport layers and emissive materials in organic light-emitting diodes (OLEDs).
• Ligand & Catalyst Design: Employed in the synthesis of sophisticated ligands for transition metal catalysis, enabling more efficient and selective chemical transformations.
• Chemical Biology & Probe Development: Utilized in the construction of molecular probes and bioconjugates for studying biological processes and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global fine chemical market.

Basic Information

Product Name	3,4-Difluoro-5-Ethoxyphenylboronic Acid
CAS No.	1162261-96-2
Molecular Formula	C8H9BF2O3
Molecular Weight	201.97 g/mol
Synonyms	(3,4-Difluoro-5-ethoxyphenyl)boronic acid; 5-Ethoxy-3,4-difluorophenylboronic acid; Boronic acid, B-(3,4-difluoro-5-ethoxyphenyl)-; 3,4-Difluoro-5-ethoxybenzeneboronic acid; (5-Ethoxy-3,4-difluorophenyl)boronic acid; CAS 1162261-96-2
EINECS	Contact for details

Quality Control

Every batch of 3,4-Difluoro-5-Ethoxyphenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions and regulatory filings. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting purity, identity, and impurity profiles as determined by advanced analytical techniques (HPLC, NMR, LC-MS).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation and maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.