Description

4-(1,1-Difluoroethyl)Phenylboronic Acid is a specialized organoboron compound featuring a difluoroethyl-substituted aromatic ring. This structure makes it a valuable building block in modern synthetic chemistry, particularly for Suzuki-Miyaura cross-coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients. The compound is supplied with a CAS number of 1162257-36-4.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides where the difluoroethyl group can improve lipophilicity and biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of novel polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and bioconjugates for studying biological processes, leveraging the boronic acid group for selective binding.
• Catalyst & Ligand Preparation: Utilized to synthesize novel ligands for transition metal catalysts used in asymmetric synthesis and other specialized reactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-(1,1-Difluoroethyl)Phenylboronic Acid
CAS No.	1162257-36-4
Molecular Formula	C8H9BF2O2
Molecular Weight	185.97 g/mol
Synonyms	[4-(1,1-Difluoroethyl)phenyl]boronic acid; 4-(1,1-Difluoroethyl)benzeneboronic acid; (4-(1,1-Difluoroethyl)phenyl)boronic acid; 1,1-Difluoro-1-(4-boronophenyl)ethane; B-[4-(1,1-Difluoroethyl)phenyl]boronic acid; 4-(Difluoroethyl)phenylboronic Acid; 4-(1,1-Difluoroethyl)benzeneboronic Acid; 1162257-36-4
EINECS	Contact for details

Quality Control

Our 4-(1,1-Difluoroethyl)Phenylboronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and production applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.