Description

2-Propoxy-5-(Trifluoromethyl)Phenylboronic Acid CAS NO 1162257-29-5 is a specialized organoboron compound, a key building block in modern synthetic chemistry. Its value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl and aryl ether motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the boronic acid group facilitates the introduction of complex aromatic systems.
• Material Science Research: Serves as a monomer or building block for creating novel organic electronic materials, liquid crystals, and polymers with tailored properties.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds, a cornerstone methodology in medicinal and process chemistry.
• Chemical Library Development: Utilized in high-throughput and combinatorial chemistry for the rapid generation of diverse compound libraries for biological screening.

Basic Information

Product Name	2-Propoxy-5-(Trifluoromethyl)Phenylboronic Acid
CAS No.	1162257-29-5
Molecular Formula	C10H12BF3O3
Molecular Weight	248.01 g/mol
Synonyms	[2-(Propoxy)-5-(trifluoromethyl)phenyl]boronic acid; 2-Propoxy-5-(trifluoromethyl)benzeneboronic acid; (2-Propoxy-5-(trifluoromethyl)phenyl)boronic acid; 5-Trifluoromethyl-2-propoxybenzeneboronic acid; Boronic acid, B-[2-(propoxy)-5-(trifluoromethyl)phenyl]-; 2-Propoxy-alpha,alpha,α-trifluoro-p-tolylboronic acid
EINECS	Contact for details

Quality Control

Every batch of our 2-Propoxy-5-(Trifluoromethyl)Phenylboronic Acid is produced and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency, which is critical for reproducible results in sensitive coupling reactions. Comprehensive analytical testing, including HPLC, NMR, and elemental analysis, is performed. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.