Description

(3S,4S)-4-Amino-3-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, stereochemically defined piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a protected amino-hydroxy piperidine scaffold, essential for constructing complex molecules with precise three-dimensional orientation. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development of active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system and infectious diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially protease inhibitors and receptor modulators.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective reactions to introduce complex amine and alcohol functionalities.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for fine-tuning pharmacokinetic properties.
• Peptidomimetics Development: Serves as a constrained, non-natural amino acid analog in the design of peptide-like bioactive compounds.
• Chemical Biology Probes: Used to create tool compounds for studying enzyme mechanisms and biological pathways.
• Process Scale-Up: Supplied for the development and optimization of scalable, GMP-compliant synthetic routes for commercial API manufacturing.

Basic Information

Product Name	(3S,4S)-4-Amino-3-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1161932-04-2
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	tert-Butyl (3S,4S)-4-amino-3-hydroxypiperidine-1-carboxylate; (3S,4S)-4-Amino-3-hydroxy-1-Boc-piperidine; 1-Boc-3S,4S-4-amino-3-hydroxypiperidine; 1-N-Boc-(3S,4S)-3-hydroxy-4-aminopiperidine; 4-Amino-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (3S,4S)-; 1-(tert-Butoxycarbonyl)-3S,4S-4-amino-3-hydroxypiperidine; (3S,4S)-1-Boc-4-amino-3-piperidinol
EINECS	Contact for details

Quality Control

Our (3S,4S)-4-Amino-3-Hydroxy-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical characterization, including chiral purity verification, to meet the stringent requirements of pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.