Description

Boc-(Trans)-4-(2-Cyano-Phenyl)-Pyrrolidine-3-Carboxylic Acid is a high-purity, protected amino acid derivative, specifically a Boc-protected pyrrolidine carboxylic acid bearing a cyano-substituted phenyl ring. This compound serves as a critical chiral building block in modern pharmaceutical research and development, enabling the synthesis of complex molecules with defined stereochemistry. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of novel active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs.
• Peptidomimetic Research: Used to incorporate constrained, non-natural amino acid motifs into peptide backbones to enhance stability and biological activity.
• Chemical Biology Probes: Serves as a precursor for developing tool compounds and probes to study enzyme function and biological pathways.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for advanced pharmaceutical intermediates under GMP-like conditions.
• Library Synthesis: A valuable building block for creating diverse compound libraries for high-throughput screening in drug discovery.
• Asymmetric Synthesis: Utilized in catalytic asymmetric transformations due to its rigid, stereodefined pyrrolidine core.

Basic Information

Product Name	Boc-(Trans)-4-(2-Cyano-Phenyl)-Pyrrolidine-3-Carboxylic Acid
CAS No.	1161787-84-3
Molecular Formula	C₁₇H₂₀N₂O₄
Molecular Weight	316.36 g/mol
Synonyms	(3R,4R)-1-[(tert-Butoxy)carbonyl]-4-(2-cyanophenyl)pyrrolidine-3-carboxylic acid; (3R,4R)-1-Boc-4-(2-cyanophenyl)pyrrolidine-3-carboxylic acid; tert-Butyl (3R,4R)-3-carboxy-4-(2-cyanophenyl)pyrrolidine-1-carboxylate; (3R,4R)-4-(2-Cyanophenyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid; Boc-(3R,4R)-4-(2-Cyanophenyl)pyrrolidine-3-carboxylic Acid; (3R,4R)-1-Boc-4-(2-cyanophenyl)-3-pyrrolidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our Boc-(Trans)-4-(2-Cyano-Phenyl)-Pyrrolidine-3-Carboxylic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. While produced to meet exacting internal standards, specifications can be aligned with customer-specific requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a dry environment to prevent moisture uptake, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.