Description

Methimazole-D3 CAS NO 1160932-07-9 is a deuterated analog of the anti-thyroid drug methimazole, where three hydrogen atoms are replaced by deuterium, serving as a critical stable isotope-labeled internal standard. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolic studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in advanced LC-MS/MS method development and validation.

Application

• Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of methimazole in biological matrices (plasma, serum, urine).
• Facilitates drug metabolism and pharmacokinetics (DMPK) studies by providing a stable, non-interfering reference for mass spectrometric detection.
• Enhances data integrity in clinical research and therapeutic drug monitoring (TDM) protocols for thyroid disorders.
• Supports pharmaceutical quality control and impurity profiling during drug substance and product development.
• Used in forensic and toxicological analysis for the accurate detection and measurement of methimazole.
• Enables regulatory compliance in bioanalytical method validation as per FDA and ICH guidelines.

Basic Information

Product Name	Methimazole-D3
CAS No.	1160932-07-9
Molecular Formula	C4H3D3N2S
Molecular Weight	117.18 g/mol
Synonyms	1-Methyl-2-mercaptoimidazole-d3; 2-Mercapto-1-methylimidazole-d3; Thiamazole-d3; Tapazole-d3; Mercazolyl-d3; Methimazole (methyl-d3); 1-Methylimidazole-2-thiol-d3; Deuterated Methimazole
EINECS	Contact for details

Quality Control

Our Methimazole-D3 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D, atom %), chemical purity (by HPLC), and confirmation of structure. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable and reproducible performance in your LC-MS/MS assays.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider keeping the container under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D, atom %)	≥ 98.0% (D3)
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.