Description

4-Chloro-2,3-Difluorophenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries, particularly in the development of active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs) via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific difluorinated biphenyl scaffolds.
• Material Science Research: Serves as a monomer or building block for creating novel organic electronic materials, such as those used in OLEDs and semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized boronic acid-based ligands for catalysis and molecular recognition applications.
• Chemical Biology & Proteomics: Utilized in the synthesis of probes and inhibitors that target enzymes or biological pathways, leveraging its specific halogen and fluorine pattern.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs serving the life sciences sector.

Basic Information

Product Name	4-Chloro-2,3-Difluorophenylboronic Acid
CAS No.	1160561-28-3
Molecular Formula	C6H4BClF2O2
Molecular Weight	191.36 g/mol
Synonyms	(4-Chloro-2,3-difluorophenyl)boronic acid; 2,3-Difluoro-4-chlorobenzeneboronic acid; 4-Chloro-2,3-difluorobenzeneboronic acid; B-(4-Chloro-2,3-difluorophenyl)boronic acid; 1160561-28-3; 4-Cl-2,3-F2-PhB(OH)2
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,3-Difluorophenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.