Description

2-Dicyclohexylphosphino-2',6'-Bis(Dimethylamino)-1,1'-Biphenyl (CPhos) is a highly specialized, Buchwald-type phosphine ligand, supplied at a minimum purity of 98%. This compound is a critical catalyst component for enabling efficient and selective cross-coupling reactions in advanced organic synthesis. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require robust and reliable catalysts for constructing complex molecular architectures. The CAS number for this product is 1160556-64-8.

Application

CPhos is a premier ligand designed for demanding catalytic transformations. Its primary applications include:

• Palladium-Catalyzed Cross-Coupling Reactions: Enabling high-yield Buchwald-Hartwig aminations, Suzuki-Miyaura couplings, and related C-N, C-O, and C-C bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Facilitating the efficient and scalable production of active pharmaceutical ingredients (APIs) and key chiral intermediates.
• Agrochemical Manufacturing: Used in the synthesis of complex, bioactive molecules for crop protection agents.
• Material Science Research: Employed in the development of novel organic electronic materials and polymers through precise coupling chemistry.
• Academic & Process R&D: A valuable tool for methodology development and optimizing reaction conditions for challenging substrates.

Basic Information

Product Name	2-Dicyclohexylphosphino-2',6'-Bis(Dimethylamino)-1,1'-Biphenyl (CPhos), Min. 98%
CAS No.	1160556-64-8
Molecular Formula	C32H49N2P
Molecular Weight	492.72 g/mol
Synonyms	CPhos Ligand; 2-Dicyclohexylphosphino-2',6'-bis(dimethylamino)biphenyl; DavePhos; Chloro(2-dicyclohexylphosphino-2',6'-bis(dimethylamino)-1,1'-biphenyl)palladium(II) precursor; Buchwald Ligand CPhos; Dicyclohexyl(2',6'-bis(dimethylamino)-[1,1'-biphenyl]-2-yl)phosphine; [1,1'-Biphenyl]-2-yl(dicyclohexyl)phosphine deriv.
EINECS	Contact for details

Quality Control

Our CPhos ligand is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Every lot is characterized by NMR (1H, 13C, 31P) and HPLC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP manufacturing requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and ensure long-term stability. Allow the container to reach room temperature in a dry environment before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 98.0%
Loss on Drying	Max. 0.5%
Residue on Ignition	Max. 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.