Description

(R)-Meo-F12-Biphep is a chiral, fluorinated biphenylphosphine ligand, a key building block in asymmetric synthesis. This high-value specialty chemical is critical for enabling highly enantioselective catalytic transformations, particularly in the pharmaceutical and fine chemical industries. It is essential for researchers and process chemists developing advanced active pharmaceutical ingredients (APIs) and complex organic molecules requiring precise stereochemical control.

Application

• As a privileged chiral ligand in asymmetric hydrogenation and cross-coupling reactions.
• Catalyst development for the synthesis of enantiomerically pure pharmaceutical intermediates.
• Research and development of novel synthetic methodologies in academic and industrial laboratories.
• Production of high-value fine chemicals and agrochemicals requiring specific chirality.
• Key component in catalyst systems for C-C and C-X bond formation with high enantiomeric excess (ee).
• Scale-up applications in GMP manufacturing for chiral drug substances.

Basic Information

Product Name	(R)-Meo-F12-Biphep
CAS No.	1160008-35-4
Molecular Formula	C26H12F12O2P2
Molecular Weight	622.31 g/mol
Synonyms	(R)-(+)-2,2'-Bis[di(3,5-bis(trifluoromethyl)phenyl)phosphino]-6,6'-dimethoxy-1,1'-biphenyl; (R)-3,5-(CF3)2C6H3-MeO-BIPHEP; (R)-DTBM-MeO-BIPHEP; (R)-Xyl-MeO-BIPHEP derivative; (R)-Bis(3,5-bis(trifluoromethyl)phenyl)(6,6'-dimethoxybiphenyl-2,2'-diyl)phosphine; (R)-MeO-F12-BIPHEP; (R)-F12-MeO-BIPHEP; (R)-F12-BIPHEP-OMe
EINECS	Contact for details

Quality Control

Our (R)-Meo-F12-Biphep is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and other critical parameters are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The product is easily oxidized and moisture-sensitive; ensure containers are sealed immediately after use and stored in a cool, dry place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.